Transcriptomic Profiles of Sepsis in the Human Brain

A study that demonstrates the transcriptomic profiles of sepsis in the human brain is featured. It offers details of the method of the study that observes 12 subjects who died of sepsis and 12 who died of a noninfectious critical illness, whose RNAs were isolated from the parietal cortex gray matter...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 201; no. 7; pp. 861 - 863
Main Authors Bustamante, Angela C., Opron, Kristopher, Ehlenbach, William J., Larson, Eric B., Crane, Paul K., Keene, C. Dirk, Standiford, Theodore J., Singer, Benjamin H.
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.04.2020
Subjects
Aged, 80 and over
Brain
Brain Diseases - etiology
Brain Diseases - genetics
Correspondence
Critical care
Female
Forensic pathology
Humans
Male
Sepsis
Sepsis - complications
Sepsis - genetics
Transcriptome
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Summary:A study that demonstrates the transcriptomic profiles of sepsis in the human brain is featured. It offers details of the method of the study that observes 12 subjects who died of sepsis and 12 who died of a noninfectious critical illness, whose RNAs were isolated from the parietal cortex gray matter. It also provides discussion of the result and indicates that it is likely the human brain, supported by modern critical care, encounters greater physiologic and metabolic insults during course of critical illness than is accounted for in animal models.
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ISSN:1073-449X
1535-4970
1535-4970
DOI:10.1164/rccm.201909-1713LE