Dissociable functional activities of cortical theta and beta oscillations in the lateral prefrontal cortex during intertemporal choice

• Published in: Scientific reports Vol. 8; no. 1; pp. 11233 - 8
• Main Authors: Gui, Dan-Yang, Yu, Tao, Hu, Zhenhong, Yan, Jiaqing, Li, Xiaoli
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 25.07.2018; Nature Publishing Group UK
• Subjects: Brain mapping; Cortex (temporal); Decision making; Economic models; Expected utility; Functional magnetic resonance imaging; Investment income; Marginal analysis; Neural networks; Neuroimaging; Prefrontal cortex; Theta rhythms
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-21150-1

The lateral prefrontal cortex (LPFC) plays an important role in the neural networks involved in intertemporal choice. However, little is known about how the neural oscillation of LPFC functions during intertemporal choice, owing to the technical limitations of functional magnetic resonance imaging and event-related brain potential recordings. Electrocorticography (ECoG) is a novel neuroimaging technique that has high spatial and temporal resolution. In this study, we used ECoG and projected the ECoG data onto individual brain spaces to investigate human intracranial cortex activity and how neural oscillations of the LPFC impact intertemporal choice. We found that neural activity of theta oscillation was significantly higher during impulsive decisions, while beta oscillation activity was significantly higher during non-impulsive ones. Our findings suggest a functional dissociation between cortical theta and beta oscillations during decision-making processes involved in intertemporal choice, and that decision outcomes may be determined by LPFC modulation, which involves neural oscillations at different frequencies.