Evaluation of dosage forms. IV. Studies on commercial phenylbutazone tablet dosage forms
In order to determine the feasibility of dissolution-dialysis as a suitable technique for in vitro evaluation, studies on commercial phenylbutazone tablets were carried out. Although disintegration time and dissolution parameters did not give a true indication of bioavailability, an excellent correl...
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Published in | Drug development and industrial pharmacy Vol. 24; no. 7; p. 599 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
01.01.1998
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Subjects | |
Online Access | Get more information |
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Summary: | In order to determine the feasibility of dissolution-dialysis as a suitable technique for in vitro evaluation, studies on commercial phenylbutazone tablets were carried out. Although disintegration time and dissolution parameters did not give a true indication of bioavailability, an excellent correlation was obtained between the dialysis rate constant (K) and various pharmacokinetic parameters obtained from bioavailability studies on human volunteers. |
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ISSN: | 0363-9045 |
DOI: | 10.3109/03639049809082360 |