Evaluation of dosage forms. IV. Studies on commercial phenylbutazone tablet dosage forms

In order to determine the feasibility of dissolution-dialysis as a suitable technique for in vitro evaluation, studies on commercial phenylbutazone tablets were carried out. Although disintegration time and dissolution parameters did not give a true indication of bioavailability, an excellent correl...

Full description

Saved in:
Bibliographic Details
Published inDrug development and industrial pharmacy Vol. 24; no. 7; p. 599
Main Authors Razdan, B, Paradkar, A R
Format Journal Article
LanguageEnglish
Published England 01.01.1998
Subjects
Adult
Biological Availability
Dosage Forms
Evaluation Studies as Topic
Humans
Linear Models
Male
Phenylbutazone - administration & dosage
Phenylbutazone - pharmacokinetics
Reference Values
Solubility
Tablets
Online AccessGet more information

Cover

More Information
Summary:In order to determine the feasibility of dissolution-dialysis as a suitable technique for in vitro evaluation, studies on commercial phenylbutazone tablets were carried out. Although disintegration time and dissolution parameters did not give a true indication of bioavailability, an excellent correlation was obtained between the dialysis rate constant (K) and various pharmacokinetic parameters obtained from bioavailability studies on human volunteers.
ISSN:0363-9045
DOI:10.3109/03639049809082360