Influence of spasmolytic analgesics on motility of sphincter of Oddi

The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg; N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdomina...

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Bibliographic Details
Published inDigestive diseases and sciences Vol. 41; no. 9; p. 1814
Main Authors Brandstätter, G, Schinzel, S, Wurzer, H
Format Journal Article
LanguageEnglish
Published United States 01.09.1996
Subjects
Analgesics, Opioid - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Female
Gastrointestinal Motility - drug effects
Humans
Male
Middle Aged
Nitroglycerin - pharmacology
Parasympatholytics - pharmacology
Single-Blind Method
Sphincter of Oddi - drug effects
Sphincter of Oddi - physiology
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Summary:The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg; N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphincter pressure and sphincter motility were measured for a 5-min period after treatment by endoscopic manometry. Nitroglycerin and dipyrone both caused a significant fall in basal sphincter pressure, while N-butylscopolamine and nitroglycerin produced a significant decrease in contraction frequency. Therefore, dipyrone, in contrast to tramadol and indomethacin, exhibits spasmolytic activity in addition to analgesia in biliary pain.
ISSN:0163-2116
1573-2568
DOI:10.1007/bf02088751