Experimental interruption of the endolymphatic duct and its effect on the DC potential in the endolymphatic sac

The endolymphatic sac (ES) of the guinea pig was isolated from the remainder of the inner ear by means of surgical interruption of the endolymphatic duct (ED). The DC potential in the ES lumen and the morphology of the ES were studied using glass micro-electrodes and a light microscope at various ti...

Full description

Saved in:
Bibliographic Details
Published inActa oto-laryngologica Vol. 112; no. 5; p. 785
Main Authors Tsujikawa, S, Yamashita, T, Meyer zum Gottesberge, A M, Tomoda, K, Kumazawa, T
Format Journal Article
LanguageEnglish
Published England 1992
Subjects
Animals
Electrophysiology
Endolymphatic Duct - pathology
Endolymphatic Duct - physiology
Endolymphatic Duct - surgery
Endolymphatic Sac - pathology
Endolymphatic Sac - physiology
Female
Guinea Pigs
Male
Online AccessGet more information

Cover

More Information
Summary:The endolymphatic sac (ES) of the guinea pig was isolated from the remainder of the inner ear by means of surgical interruption of the endolymphatic duct (ED). The DC potential in the ES lumen and the morphology of the ES were studied using glass micro-electrodes and a light microscope at various time intervals after the interruption of ED. The DC potential did not significantly change 1 h postoperatively, compared to findings in the non-operated ear, but a significant decrease of the DC potential was observed after 1, 3 and 7 days postoperatively. A histologically-stainable substance in the ES lumen was enhanced on the operated side. The isolated ES shows a disturbance of mechanism(s) maintaining the DC potential and there is a secretion of a stainable substance into its lumen.
ISSN:0001-6489
DOI:10.3109/00016489209137475