The molecular epidemiology of Treponema pallidum subspecies pallidum

Pathogens adapt and evolve in response to pressures exerted by host environments, leading to generation of genetically diverse variants. Treponema pallidum subspecies pallidum displays a substantial amount of interstrain diversity. These variants have been identified in various parts of the world, i...

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Bibliographic Details
Published inSexual health Vol. 12; no. 2; pp. 141 - 147
Main Authors Ma, Daphne Y, Giacani, Lorenzo, Centurión-Lara, Arturo
Format Journal Article
LanguageEnglish
Published Australia CSIRO 01.04.2015
Subjects
Adaptation
Deoxyribonucleic acid
Disease control
DNA
Drug resistance
Epidemiology
Genetic diversity
Genomes
Health surveillance
Infections
Medical laboratories
Methods
Mutation
Pathogenesis
Public health
Studies
Treponema pallidum
United States > US
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Summary:Pathogens adapt and evolve in response to pressures exerted by host environments, leading to generation of genetically diverse variants. Treponema pallidum subspecies pallidum displays a substantial amount of interstrain diversity. These variants have been identified in various parts of the world, indicating transmission linkage between geographical regions. Genotyping is based on molecular characterisation of various loci in the syphilis treponeme genome, but still require further development and continued research, as new bacterial types are continually being detected. The goal for studying the molecular epidemiology of Treponema pallidum variants is the global monitoring of the transmission of genetically distinct organisms with different drug sensitivities and, potentially, different virulence proprieties.
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Present address: Emory University, Department of Pediatrics, Yerkes Vaccine Center, 954 Gatewood Road, Atlanta, GA 30329, USA
ISSN:1448-5028
1449-8987
DOI:10.1071/SH14197