Silencing of CD86 in dendritic cells by small interfering RNA regulates cytokine production in T cells from patients with allergic rhinitis in vitro

The aim of the present study was to investigate the expression and role of the co‑stimulatory molecule T‑lymphocyte activation antigen CD86 (CD86) in dendritic cells (DCs) from the peripheral blood of patients with allergic rhinitis (AR) compared with those from healthy individuals. It was observed...

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Published inMolecular medicine reports Vol. 20; no. 4; pp. 3893 - 3900
Main Authors Sun, Rong, Yang, Yang, Gu, Zheng, Tang, Xinye, Zhang, Cheng, Kou, Wei, Wei, Ping
Format Journal Article
LanguageEnglish
Published Greece Spandidos Publications 01.10.2019
Spandidos Publications UK Ltd
Subjects
Allergic rhinitis
Allergies
Antigens
Antigens, CD - genetics
Antigens, Differentiation, Myelomonocytic - genetics
Asthma
Bone morphogenetic proteins
CD80 antigen
CD86 antigen
Cell activation
Cells, Cultured
Coculture Techniques
Comparative analysis
Cytokines
Cytokines - genetics
Dendritic cells
Dendritic Cells - metabolism
Down-Regulation
Experiments
Humans
Hypersensitivity
Infection
Inflammation
Interleukin 5
Interleukins
Kinases
Lymphocytes
Lymphocytes T
Neomycin
Peripheral blood
Proteins
Rhinitis
Rhinitis, Allergic - genetics
RNA
RNA Interference
RNA, Small Interfering - genetics
Scientific equipment industry
siRNA
Studies
T cells
T-Lymphocytes - metabolism
Transfection
Up-Regulation
United States
Online AccessGet full text

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Abstract The aim of the present study was to investigate the expression and role of the co‑stimulatory molecule T‑lymphocyte activation antigen CD86 (CD86) in dendritic cells (DCs) from the peripheral blood of patients with allergic rhinitis (AR) compared with those from healthy individuals. It was observed that mature DCs from the peripheral blood of patients with AR expressed high levels of the co‑stimulatory molecule CD86, but not CD80, compared with healthy control subjects. CD86 expression levels in DCs decreased significantly following transfection with siRNA in a lentiviral vector. Furthermore, the level of transforming growth factor‑β1 produced by T cells co‑cultured with DCs was significantly increased in the siRNA group, while interleukin (IL)‑4 and IL‑5 production was significantly decreased. The findings of the present study indicated that CD86 may play a pivotal role in the regulatory T cell/type 2 helper T cell imbalance in allergic inflammation.
AbstractList The aim of the present study was to investigate the expression and role of the co-stimulatory molecule T-lymphocyte activation antigen CD86 (CD86) in dendritic cells (DCs) from the peripheral blood of patients with allergic rhinitis (AR) compared with those from healthy individuals. It was observed that mature DCs from the peripheral blood of patients with AR expressed high levels of the co-stimulatory molecule CD86, but not CD80, compared with healthy control subjects. CD86 expression levels in DCs decreased significantly following transfection with siRNA in a lentiviral vector. Furthermore, the level of transforming growth factor-β1 produced by T cells co-cultured with DCs was significantly increased in the siRNA group, while interleukin (IL)-4 and IL-5 production was significantly decreased. The findings of the present study indicated that CD86 may play a pivotal role in the regulatory T cell/type 2 helper T cell imbalance in allergic inflammation.
The aim of the present study was to investigate the expression and role of the co‑stimulatory molecule T‑lymphocyte activation antigen CD86 (CD86) in dendritic cells (DCs) from the peripheral blood of patients with allergic rhinitis (AR) compared with those from healthy individuals. It was observed that mature DCs from the peripheral blood of patients with AR expressed high levels of the co‑stimulatory molecule CD86, but not CD80, compared with healthy control subjects. CD86 expression levels in DCs decreased significantly following transfection with siRNA in a lentiviral vector. Furthermore, the level of transforming growth factor‑β1 produced by T cells co‑cultured with DCs was significantly increased in the siRNA group, while interleukin (IL)‑4 and IL‑5 production was significantly decreased. The findings of the present study indicated that CD86 may play a pivotal role in the regulatory T cell/type 2 helper T cell imbalance in allergic inflammation.The aim of the present study was to investigate the expression and role of the co‑stimulatory molecule T‑lymphocyte activation antigen CD86 (CD86) in dendritic cells (DCs) from the peripheral blood of patients with allergic rhinitis (AR) compared with those from healthy individuals. It was observed that mature DCs from the peripheral blood of patients with AR expressed high levels of the co‑stimulatory molecule CD86, but not CD80, compared with healthy control subjects. CD86 expression levels in DCs decreased significantly following transfection with siRNA in a lentiviral vector. Furthermore, the level of transforming growth factor‑β1 produced by T cells co‑cultured with DCs was significantly increased in the siRNA group, while interleukin (IL)‑4 and IL‑5 production was significantly decreased. The findings of the present study indicated that CD86 may play a pivotal role in the regulatory T cell/type 2 helper T cell imbalance in allergic inflammation.
The aim of the present study was to investigate the expression and role of the co-stimulatory molecule T-lymphocyte activation antigen CD86 (CD86) in dendritic cells (DCs) from the peripheral blood of patients with allergic rhinitis (AR) compared with those from healthy individuals. It was observed that mature DCs from the peripheral blood of patients with AR expressed high levels of the co-stimulatory molecule CD86, but not CD80, compared with healthy control subjects. CD86 expression levels in DCs decreased significantly following transfection with siRNA in a lentiviral vector. Furthermore, the level of transforming growth factor-[beta]1 produced by T cells co-cultured with DCs was significantly increased in the siRNA group, while interleukin (IL)-4 and IL-5 production was significantly decreased. The findings of the present study indicated that CD86 may play a pivotal role in the regulatory T cell/type 2 helper T cell imbalance in allergic inflammation.
The aim of the present study was to investigate the expression and role of the co-stimulatory molecule T-lymphocyte activation antigen CD86 (CD86) in dendritic cells (DCs) from the peripheral blood of patients with allergic rhinitis (AR) compared with those from healthy individuals. It was observed that mature DCs from the peripheral blood of patients with AR expressed high levels of the co-stimulatory molecule CD86, but not CD80, compared with healthy control subjects. CD86 expression levels in DCs decreased significantly following transfection with siRNA in a lentiviral vector. Furthermore, the level of transforming growth factor-[beta]1 produced by T cells co-cultured with DCs was significantly increased in the siRNA group, while interleukin (IL)-4 and IL-5 production was significantly decreased. The findings of the present study indicated that CD86 may play a pivotal role in the regulatory T cell/type 2 helper T cell imbalance in allergic inflammation. Key words: allergic rhinitis, T-lymphocyte activation antigen CD86, small interfering RNA, dendritic cells, regulatory T cells
The aim of the present study was to investigate the expression and role of the co‑stimulatory molecule T‑lymphocyte activation antigen CD86 (CD86) in dendritic cells (DCs) from the peripheral blood of patients with allergic rhinitis (AR) compared with those from healthy individuals. It was observed that mature DCs from the peripheral blood of patients with AR expressed high levels of the co‑stimulatory molecule CD86, but not CD80, compared with healthy control subjects. CD86 expression levels in DCs decreased significantly following transfection with siRNA in a lentiviral vector. Furthermore, the level of transforming growth factor‑β1 produced by T cells co‑cultured with DCs was significantly increased in the siRNA group, while interleukin (IL)‑4 and IL‑5 production was significantly decreased. The findings of the present study indicated that CD86 may play a pivotal role in the regulatory T cell/type 2 helper T cell imbalance in allergic inflammation.
Audience Academic
Author Sun, Rong
Wei, Ping
Zhang, Cheng
Gu, Zheng
Kou, Wei
Tang, Xinye
Yang, Yang
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CitedBy_id crossref_primary_10_3389_fphar_2022_1096984
crossref_primary_10_1080_08820139_2023_2197940
crossref_primary_10_3389_fncel_2024_1317125
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Snippet The aim of the present study was to investigate the expression and role of the co‑stimulatory molecule T‑lymphocyte activation antigen CD86 (CD86) in dendritic...
The aim of the present study was to investigate the expression and role of the co-stimulatory molecule T-lymphocyte activation antigen CD86 (CD86) in dendritic...
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SubjectTerms Allergic rhinitis
Allergies
Antigens
Antigens, CD - genetics
Antigens, Differentiation, Myelomonocytic - genetics
Asthma
Bone morphogenetic proteins
CD80 antigen
CD86 antigen
Cell activation
Cells, Cultured
Coculture Techniques
Comparative analysis
Cytokines
Cytokines - genetics
Dendritic cells
Dendritic Cells - metabolism
Down-Regulation
Experiments
Humans
Hypersensitivity
Infection
Inflammation
Interleukin 5
Interleukins
Kinases
Lymphocytes
Lymphocytes T
Neomycin
Peripheral blood
Proteins
Rhinitis
Rhinitis, Allergic - genetics
RNA
RNA Interference
RNA, Small Interfering - genetics
Scientific equipment industry
siRNA
Studies
T cells
T-Lymphocytes - metabolism
Transfection
Up-Regulation
Title Silencing of CD86 in dendritic cells by small interfering RNA regulates cytokine production in T cells from patients with allergic rhinitis in vitro
URI https://www.ncbi.nlm.nih.gov/pubmed/31485639
https://www.proquest.com/docview/2297885474
https://www.proquest.com/docview/2285110417
Volume 20
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