Superior sagittal sinus thrombosis complicating maintenance treatment for acute lymphoblastic leukemia

A girl with acute lymphoblastic leukemia in remission had two seizures during the maintenance phase of her treatment. Magnetic resonance imaging with angiography identified a superior sagittal sinus thrombosis as the likely explanation for her symptoms. Possible causes are considered, and previous r...

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Bibliographic Details
Published inPediatric hematology and oncology Vol. 13; no. 3; p. 287
Main Authors Nicholson, J C, Darmady, J M, Kohler, J A
Format Journal Article
LanguageEnglish
Published England 1996
Subjects
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Ataxia
Central Nervous System Neoplasms - prevention & control
Female
Humans
Injections, Spinal
Intracranial Embolism and Thrombosis - chemically induced
Intracranial Embolism and Thrombosis - diagnosis
Magnetic Resonance Angiography
Methotrexate - administration & dosage
Methotrexate - adverse effects
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Prednisolone - administration & dosage
Seizures
Vincristine - administration & dosage
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Summary:A girl with acute lymphoblastic leukemia in remission had two seizures during the maintenance phase of her treatment. Magnetic resonance imaging with angiography identified a superior sagittal sinus thrombosis as the likely explanation for her symptoms. Possible causes are considered, and previous reports of the neurotoxicity of agents used in the treatment of leukemia are reviewed.
ISSN:0888-0018
DOI:10.3109/08880019609030829