IL-17 enhances the migration of B cells during asthma by inducing CXCL13 chemokine production in structural lung cells

Here, we report a positive correlation between expression of IL-17 cytokines with CXCL13+ cells and B cells numbers in asthmatic airways. IL-17A/F stimulated CXCL13 release from fibroblast and endothelial cells which induced B cells chemotaxis.

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 139; no. 2; pp. 696 - 699.e5
Main Authors Al-Kufaidy, Roua, MSc, Vazquez-Tello, Alejandro, PhD, BaHammam, Ahmed S., MD, Hamid, Qutayba, MD, PhD, Al-Muhsen, Saleh, MD, Halwani, Rabih, PhD
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 01.02.2017
Subjects
Adult
Allergy and Immunology
Asthma
Asthma - immunology
Asthma - pathology
B-Lymphocytes, Regulatory - immunology
B-Lymphocytes, Regulatory - pathology
Cell Movement - immunology
Cells, Cultured
Chemokine CXCL13 - immunology
Cytokines
Female
Fibroblasts
Humans
Immunoglobulins
Interleukin-17 - immunology
Kinases
Lung - immunology
Lung - pathology
Male
Proteins
Smooth muscle
Software
Statistical analysis
Th17 Cells - immunology
Th17 Cells - pathology
NF-κB
Bronchial asthma
B cells
CXCL13
IL-17
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Summary:Here, we report a positive correlation between expression of IL-17 cytokines with CXCL13+ cells and B cells numbers in asthmatic airways. IL-17A/F stimulated CXCL13 release from fibroblast and endothelial cells which induced B cells chemotaxis.
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ObjectType-Article-2
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ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.07.037