Veno-occlusive disease-like hepatotoxicity in two children receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney

• Published in: Pediatric hematology and oncology Vol. 15; no. 1; p. 85
• Main Authors: Hazar, V, Kutluk, T, Akyüz, C, Varan, A, Yariş, N, Büyükpamukçu, M
• Format: Journal Article
• Language: English
• Published: England 01.01.1998
• Subjects: Antineoplastic Combined Chemotherapy Protocols - adverse effects; Dactinomycin - administration & dosage; Diagnosis, Differential; Epirubicin - administration & dosage; Hepatic Veno-Occlusive Disease - chemically induced; Humans; Infant; Kidney Neoplasms - drug therapy; Liver - drug effects; Liver - pathology; Male; Sarcoma, Clear Cell - drug therapy; Vincristine - administration & dosage; Wilms Tumor - drug therapy
• ISSN: 0888-0018
• DOI: 10.3109/08880019809009513

We report two pediatric cases who developed veno-occlusive disease-like hepatotoxicity while receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney. The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed. Other possible causes of hepatotoxicity were excluded. Recovery was observed with supportive therapy after 2 and 1 weeks, respectively. After recovery, the children tolerated continued chemotherapy without any decrease in the doses of drugs. We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.