An Age of Sodium-Glucose Cotransporter-2 Inhibitor Priority: Are We Ready?

• Published in: Diabetes & Metabolism Journal Vol. 43; no. 5; pp. 578 - 581
• Main Author: Seo, Ji A
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Diabetes Association 01.10.2019; Korean Diabetes Association / Daehan Dangnyobyeong Hakoe; 대한당뇨병학회
• Subjects: Acute coronary syndromes; Antidiabetics; Atherosclerosis; Cardiovascular disease; Clinical medicine; Clinical practice guidelines; Clinical trials; Conflicts of interest; Diabetes; Drugs; Editorial; Glucose; Heart failure; Patients; Physicians; Side effects; 내과학
• ISSN: 2233-6079; 2233-6087
• DOI: 10.4093/dmj.2019.0173

[...]followed by the striking results of the EMPA-REG OUTCOME study (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) [5], a series of clinical trials demonstrated the protective effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors on cardiovascular and renal complications [678]. [...]most updated treatment guidelines recommend SGLT2 inhibitors to be considered as the preferred choice for T2DM patients with atherosclerotic cardiovascular disease, heart failure, nephropathy, or multiple risk factors [910]; SGLT2 inhibitors are accordingly being used in an increasing number of Korean T2DM patients. [...]SGLT2 inhibitors would have been preferable in obese patients with renal or cardiovascular risk. [...]the consequences of switching therapy in this study might have included specific clinical situations, resulting in drug switches (e.g., side effects on existing drugs). [...]the results of switching therapy to SGLT2 inhibitors are interesting because doctors often experience clinical situations in which they want to change prescriptions to SGLT2 inhibitors for various reasons including glucose control. [...]switching therapy may be a relatively common use pattern in Korea, where insurance coverage is restricted by number of drug classes used. Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis.