Plasmin inhibitory effect of rat tissues: comparison with antiplasmin activity of plasma

Plasmin inhibition by rat tissue extracts was compared with rat plasma plasmin inhibition. Nine different tissues were extracted with an acid acetate-buffer (lung, heart, brain, adrenal, aorta, skeletal muscle, spleen and liver) or with KSCN-buffer (kidney), and antiplasmin activity was evaluated by...

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Bibliographic Details
Published inScandinavian journal of clinical and laboratory investigation Vol. 51; no. 7; p. 599
Main Authors Padró, T, van den Hoogen, C M, Emeis, J J
Format Journal Article
LanguageEnglish
Published England 1991
Subjects
alpha-2-Antiplasmin - physiology
Animals
Fibrinolysin - antagonists & inhibitors
Hydrogen-Ion Concentration
Rats
Rats, Inbred Strains
Tissue Extracts - physiology
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Summary:Plasmin inhibition by rat tissue extracts was compared with rat plasma plasmin inhibition. Nine different tissues were extracted with an acid acetate-buffer (lung, heart, brain, adrenal, aorta, skeletal muscle, spleen and liver) or with KSCN-buffer (kidney), and antiplasmin activity was evaluated by a spectrophotometric method. All tissue extracts inhibited plasmin dose-dependently; the amount of plasmin inhibited by a fixed amount of extract depended upon the tissue. In rat plasma, antiplasmin activity was acid-labile, but acid treatment did not affect the plasmin inhibitory effect of tissues extracts.
ISSN:0036-5513
1502-7686
DOI:10.3109/00365519109104570