Pharmacokinetics of Ceftazidime in Febrile Neutropenic Patients

• Published in: Scandinavian journal of infectious diseases Vol. 33; no. 3; pp. 222 - 226
• Main Author: Anna Nyhlen, Bengt Ljungberg, Ingrid Nilsson-Ehle
• Format: Journal Article
• Language: English
• Published: Basingstoke Informa UK Ltd 2001; Taylor & Francis
• Subjects: Adult; Aged; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Area Under Curve; Biological and medical sciences; Ceftazidime - administration & dosage; Ceftazidime - pharmacokinetics; Cephalosporins - administration & dosage; Cephalosporins - pharmacokinetics; Female; Fever - etiology; Fever - metabolism; Glomerular Filtration Rate; Half-Life; Humans; Injections, Intravenous; Leukemia - complications; Leukemia - metabolism; Male; Medical sciences; Microbial Sensitivity Tests; Middle Aged; Neutropenia - etiology; Neutropenia - metabolism; Pharmacology. Drug treatments; Human; Intravenous administration; Leukopenia; β-Lactams; Hemopathy; Concentration; Fever; Blood plasma; Antibiotic; Chemotherapy; Cephalosporin derivatives; Bolus injection; Treatment; Pharmacokinetics; Ceftazidime; Neutropenia
• ISSN: 0036-5548; 1651-1980
• DOI: 10.1080/00365540151060941

Eight patients with fever and neutropenia were given 2 g of ceftazidime i.v. as a bolus injection over the course of 3 min. The pharmacokinetic variables for ceftazidime were similar to those found previously in febrile, acutely ill, non-neutropenic patients. The area under the plasma-concentration-time curve was significantly smaller, and the terminal half-life (t1/2