Taking Care of Persistent Sleepiness in Patients with Sleep Apnea

To put the potential effect of these small changes into perspective, it has been estimated that a 2 mm Hg decrease in average blood pressure in the general population would reduce all-cause mortality annually by 3%, whereas a 2–3 beats per minute increase in heart rate in healthy middle-aged men has...

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Published inAmerican journal of respiratory and critical care medicine Vol. 199; no. 11; pp. 1310 - 1311
Main Authors Kapur, Vishesh K, Donovan, Lucas M
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.06.2019
Subjects
Blood pressure
Disorders of Excessive Somnolence
Dopamine
Drug dosages
Heart rate
Humans
Hypoxia
Insomnia
Investigations
Mortality
Sleep apnea
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Sleep disorders
Sleepiness
United States > US
Puget Sound
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Summary:To put the potential effect of these small changes into perspective, it has been estimated that a 2 mm Hg decrease in average blood pressure in the general population would reduce all-cause mortality annually by 3%, whereas a 2–3 beats per minute increase in heart rate in healthy middle-aged men has been estimated to increase mortality over the course of 16 years by 3.2–4.8% (6, 7). The investigators used a double-blind placebo control design, assessed a variety of doses, incorporated both objective and subjective measures of sleepiness, and monitored for a reasonable range of adverse effects over the course of 12 weeks. Jensen MT, Suadicani P, Hein HO, Gyntelberg F. Elevated resting heart rate, physical fitness and all-cause mortality: a 16-year follow-up in the Copenhagen Male Study.
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ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201812-2291ED