Predicting cisplatin-induced acute kidney injury by urinary neutrophil gelatinase-associated lipocalin excretion: a pilot prospective case-control study

• Published in: Nephron Vol. 115; no. 2; p. c154
• Main Authors: Gaspari, Flavio, Cravedi, Paolo, Mandalà, Mario, Perico, Norberto, de Leon, Felipe Rodríguez, Stucchi, Nadia, Ferrari, Silvia, Labianca, Roberto, Remuzzi, Giuseppe, Ruggenenti, Piero
• Format: Journal Article
• Language: English
• Published: Switzerland S. Karger AG 01.06.2010
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - diagnosis; Acute Kidney Injury - urine; Acute-Phase Proteins - urine; Aged; Biomarkers - urine; Case-Control Studies; Cisplatin - adverse effects; Female; Follow-Up Studies; Humans; Lipocalin-2; Lipocalins - urine; Male; Middle Aged; Pilot Projects; Predictive Value of Tests; Prospective Studies; Proto-Oncogene Proteins - urine
• ISSN: 1660-8151; 1660-2110; 2235-3186
• DOI: 10.1159/000312879

Nephrotoxicity is the major limitation to cisplatin therapy for solid tumors. We aimed at evaluating whether early increases in serum/urine levels of neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of tubular damage and regeneration, predict cisplatin-induced acute kidney injury (AKI). We compared changes in serum creatinine and serum/urine NGAL levels (ELISA assay) at 1 and 4 h and 1, 2, 3, 7 and 15 days after cisplatin infusion (70-80 mg/m(2)) versus baseline in 12 consecutive cancer patients (cases) with AKI (>25% serum creatinine increase vs. baseline) and 12 consecutive controls without AKI. Baseline characteristics and posttreatment serum NGAL levels were similar in both groups. Urinary NGAL levels increased significantly more in cases than in controls at 1, 2, 3 and 15 days after cisplatin. The NGAL increase preceded AKI by 4.5 days and the NGAL increase at day 2 after cisplatin independently predicted AKI (p < 0.05). Six cases with residual kidney dysfunction at 15 days showed a trend to earlier and higher increase in urinary NGAL levels compared to cases with renal function recovery. An early increase in urinary NGAL excretion may help in identifying patients at risk of cisplatin-induced AKI who might benefit from innovative treatments to prevent cisplatin nephrotoxicity.