Lipoprotein(a) in relation to acute phase reaction in patients with rheumatoid arthritis and polymyalgia rheumatica

The effect of altered inflammatory activity, as reflected by acute phase protein levels, on the concentration of lipoprotein(a) was analysed in 51 patients with rheumatoid arthritis (RA), and in 25 patients with polymyalgia rheumatica (PMR). Despite significantly decreased acute phase proteins in RA...

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Published inScandinavian journal of clinical and laboratory investigation Vol. 55; no. 4; p. 309
Main Authors Wållberg-Jonsson, S, Uddhammar, A, Dahlén, G, Rantapää-Dahlqvist, S
Format Journal Article
LanguageEnglish
Published England 1995
Subjects
Acute-Phase Proteins - metabolism
Acute-Phase Reaction
Adult
Aged
Aged, 80 and over
Arthritis, Rheumatoid - blood
Blood Sedimentation
Cholesterol - blood
Female
Haptoglobins - analysis
Humans
Lipoprotein(a) - blood
Male
Middle Aged
Orosomucoid - analysis
Polymyalgia Rheumatica - blood
Triglycerides - blood
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Summary:The effect of altered inflammatory activity, as reflected by acute phase protein levels, on the concentration of lipoprotein(a) was analysed in 51 patients with rheumatoid arthritis (RA), and in 25 patients with polymyalgia rheumatica (PMR). Despite significantly decreased acute phase proteins in RA, the Lp(a) concentration increased significantly between the two observations in the group as a whole. In one subgroup with initially high Lp(a) levels, large intraindividual variations between the samplings and a high correlation to the ESR changes were found. Another subgroup with initially low levels showed small variations of Lp(a) without correlation to any acute phase reactant. In the PMR group, Lp(a) decreased in line with diminishing acute phase reactivity.
ISSN:0036-5513
DOI:10.3109/00365519509104968