Interleukin-10 Production in Response to Amyloid-β Differs between Slow and Fast Decliners in Patients with Alzheimer's Disease

• Published in: Journal of Alzheimer's disease Vol. 46; no. 4; p. 837
• Main Authors: Asselineau, Delphine, Benlhassan, Khadija, Arosio, Beatrice, Mari, Daniela, Ferri, Evelyn, Casati, Martina, Gussago, Cristina, Tedone, Enzo, Annoni, Giorgio, Mazzola, Paolo, Piette, Francois, Belmin, Joel, Pariel, Sylvie, Bornand, Anne, Beaudeux, Jean-Louis, Doulazmi, Mohamed, Mariani, Jean, Bray, Dorothy H
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2015
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Amyloid beta-Peptides - pharmacology; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Genotype; Humans; Interferon-alpha - genetics; Interleukin-10 - metabolism; Interleukin-6 - metabolism; Leukocytes, Mononuclear - drug effects; Male; Mental Status Schedule; Middle Aged; Statistics, Nonparametric; peripheral blood mononuclear cells; IFN-γ; Alzheimer’s disease; disease progression; single nucleotide polymorphisms; interleukin-10; interleukin-6
• ISSN: 1875-8908
• DOI: 10.3233/JAD-142832

We investigated IL-10 and IL-6 production in amyloid-β (Aβ) stimulated peripheral blood mononuclear cells (PBMCs) in twenty Alzheimer's disease (AD) patients with slow progression, eleven with fast progression, and twenty age-matched controls. Promoter polymorphisms in IL-10 (position -592, -819, -1082), IL-6 (-174), transforming growth factor-β1 (TGF-β1) (-10, -25), interferon-γ (IFN-γ) (-874), and tumor necrosis factor-α (TNF-α) (-308) genes were analyzed. IL-10 production after Aβ stimulation was high in PBMCs from slow decliners and almost completely abrogated in fast decliners. Association between AA IFN-γ low-producing genotype and fast progression was demonstrated. Investigations in a larger sample will clarify these findings.