Myocardial release of troponin T after coronary bypass surgery

The temporal changes in cardiac S-troponin T, S-creatine kinase-MB(S-CK-MB)mass and S-myoglobin were studied for 5 days after coronary bypass grafting in 70 patients. Perioperative infarction occurred in ten patients (2 Q wave, 8 non-Q wave). All three markers showed significant increase even in pat...

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Bibliographic Details
Published inScandinavian journal of thoracic and cardiovascular surgery Vol. 28; no. 2; p. 67
Main Authors Källner, G, Lindblom, D, Forssell, G, Kallner, A
Format Journal Article
LanguageEnglish
Published Sweden 1994
Subjects
Aged
Aged, 80 and over
Alanine Transaminase - blood
Aspartate Aminotransferases - blood
Biomarkers - blood
Cardiopulmonary Bypass
Coronary Artery Bypass - adverse effects
Creatine Kinase - blood
Electrocardiography
Female
Humans
Intraoperative Complications - blood
Isoenzymes
Male
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - physiopathology
Myocardium - metabolism
Myoglobin - blood
Time Factors
Troponin - blood
Troponin T
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Summary:The temporal changes in cardiac S-troponin T, S-creatine kinase-MB(S-CK-MB)mass and S-myoglobin were studied for 5 days after coronary bypass grafting in 70 patients. Perioperative infarction occurred in ten patients (2 Q wave, 8 non-Q wave). All three markers showed significant increase even in patients without signs of perioperative infarction. Within 8-12 hours their levels rose significantly (p < 0.001) more in the infarction than in the non-infarction cases. Troponin T and CK-MBmass both showed early (< 8-12 h) peaks in patients with perioperative infarction. CK-MBmass returned to near normal levels within 48-72 hours, whereas troponin T remained markedly increased throughout the observation. Myoglobin concentrations varied widely among the infarction cases. In the non-infarction group, troponin T and CK-MBmass (but not myoglobin) were related to the aortic cross-clamp time. Troponin T (but not CK-MBmass) remained elevated throughout the study period in patients with longer cross-clamp times. These findings may indicate continuous release from damaged myocardium in cases of perioperative infarction. Troponin T and CK-MBmass can serve as markers of perioperative infarction and troponin T may also be useful as a marker in studies on myocardial protection.
ISSN:0036-5580
DOI:10.3109/14017439409100165