EXPERIMENTAL MODEL FOR LOCAL APPLICATION OF GROWTH FACTORS IN SKIN RE-EPITHELIALISATION

• Published in: Scandinavian journal of plastic and reconstructive surgery and hand surgery Vol. 34; no. 3; pp. 199 - 206
• Main Author: Garcia, X. Santos Heredero, Á. Izquierdo Hernandez, E. Pascual Peña, G. Bilbao Gonzalez de Aledo, C. Hamann, S.Sanz
• Format: Journal Article
• Language: English
• Published: Basingstoke Informa UK Ltd 2000; Taylor & Francis
• Subjects: Animals; Biological and medical sciences; Epidermal Growth Factor - administration & dosage; Epithelium; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2 - administration & dosage; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Growth Substances - administration & dosage; Male; Medical sciences; Pharmacology. Drug treatments; Rats; Rats, Wistar; Skin - drug effects; Skin plastic surgery; Skin, nail, hair, dermoskeleton; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Animal model; Skin disease; Rat; Induction; Cytokine; Rodentia; Basic fibroblast growth factor; Keratinocyte growth factor; Experimental study; Trauma; Wound; Plasty; Local administration; Vertebrata; Chemotherapy; Mammalia; Epidermal growth factor; Treatment; Polypeptide; Surgery; Skin; Biological effect; Growth factor
• ISSN: 0284-4311; 1651-2073
• DOI: 10.1080/02844310050159765

We did an experimental study to assess the effects of different growth factors on re-epithelialisation of skin wounds by creating a partial-thickness defect in rats with a handle dermatome. Three different growth factors that are particularly involved in the re-epithelialisation phase of wound repair (epidermal growth factor (EGF), keratinocyte growth factor (KGF), and basic fibroblast growth factor (FGF-b) n