Surfactant protein D: a predictor for severity of community-acquired pneumonia in children

• Published in: Pediatric research Vol. 91; no. 3; pp. 665 - 671
• Main Authors: Saleh, Nagwan Yossery, Ibrahem, Reda Abdel Latif, Saleh, Amany Abdel Hakim, Soliman, Shimaa El Shafey, Mahmoud, Asmaa Abdel Sameea
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.02.2022; Nature Publishing Group US
• Subjects: Child; Clinical; Community-Acquired Infections - diagnosis; Humans; Hypoxia; Mortality; Pediatrics; Pneumonia; Pneumonia - diagnosis; Prospective Studies; Pulmonary Surfactant-Associated Protein D; Sepsis; Severity of Illness Index; Surfactants; Ventilators
• ISSN: 0031-3998; 1530-0447
• DOI: 10.1038/s41390-021-01492-9

Surfactant protein D (SP-D) is a promising biomarker proposed for the prediction of community-acquired pneumonia (CAP) severity. Therefore, we aimed to assess the role of SP-D in the prediction of CAP severity in pediatric patients. A prospective cohort study was carried out at the Pediatric Intensive Care Unit (PICU) and wards of Menoufia University Hospital. We recruited 112 children admitted into wards with pneumonia (simple pneumonia) and 68 children admitted into PICU with severe pneumonia (PICU admitted). World Health Organization (WHO) classification and mortality predictive scores were calculated to determine the severity of pneumonia for the two groups, including the Pediatric Respiratory Severity Score (PRESS) and the Predisposition, Insult, Response, and Organ dysfunction modified Score (PIROm). SP-D was measured at admission. The SP-D level was significantly lower in patients with simple pneumonia than in patients with severe pneumonia (P < 0.001). SP-D was significantly higher among children with severe pneumonia, as determined by WHO, PRESS, and PIROm (P = 0.001). SP-D was significantly higher among children with mechanical ventilation, shock, hypoxia, sepsis, and mortality. Receiver operating characteristic curve analysis for SP-D showed that the area under the curve was 0.741 (P value < 0.001), with a sensitivity of 85.3% and a specificity of 44.6%. Serum SP-D level has a predictive value for the detection of community-acquired pneumonia severity in children. SP-D is a good predictor for the detection of CAP severity in hospitalized children. SP-D was correlated with severity scores and was associated with indicators of CAP severity, including mechanical ventilation, shock, hypoxia, sepsis, and mortality.