Strategic design of a Mussel-inspired in situ reduced Ag/Au-Nanoparticle Coated Magnesium Alloy for enhanced viability, antibacterial property and decelerated corrosion rates for degradable implant Applications

• Published in: Scientific reports Vol. 9; no. 1; p. 117
• Main Authors: Rezk, Abdelrahman I, Ramachandra Kurup Sasikala, Arathyram, Nejad, Amin Ghavami, Mousa, Hamouda M, Oh, Young Min, Park, Chan Hee, Kim, Cheol Sang
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 15.01.2019; Nature Publishing Group UK
• Subjects: Alloys - therapeutic use; Animals; Anti-Bacterial Agents - pharmacology; Biocompatibility; Catechol; Cell adhesion; Cells, Cultured; Coated Materials, Biocompatible - pharmacology; Coatings; Corrosion; Dopamine; Gold - pharmacology; Hydrochloric acid; Hydrofluoric Acid - pharmacology; Indoles - pharmacology; Magnesium; Magnesium alloys; Materials Testing; Metal Nanoparticles; Nanoparticles; Polymers - pharmacology; Prostheses and Implants; Silver; Silver - pharmacology; Surface Properties
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-36545-3

Magnesium (Mg) and its alloys have attracted much attention as a promising candidate for degradable implant applications however the rapid corrosion of magnesium inside the human body greatly limits its use as an implant material. Therefore, coating the alloy surface with a multifunctional film is a promising way to overcome the drawbacks. Here we propose for the first time a multifunction layer coating to enhance the cell viability, antibacterial property and decelerated corrosion rates to act as a novel material to be used for degradable implant Applications. For that, the magnesium alloy (AZ31) was first treated with hydrofluoric acid (HF) and then dopamine tris Hydrochloric acid (tris-HCL) solution. The reducing catechol groups in the polydopamine (PD) layer subsequently immobilize silver/gold ions in situ to form uniformly dispersed Ag/Au nanoparticles on the coating layer. The successful formation of Ag/Au nanoparticles on the HF-PD AZ31 alloy was confirmed using XPS and XRD, and the morphology of all the coated samples were investigated using SEM images. The alloy with HF-PDA exhibit enhanced cell attachment and proliferation. Moreover, the nanoparticle immobilized HF-PD alloy exhibited dramatic corrosion resistance enhancement with superior antibacterial properties and accountable biocompatibility. Thus the result suggest that HF-PD Ag/Au alloy has great potential in the application of degradable implant and the surface modification method is of great significance to determine its properties.