Persistent Polyclonal Lymphocytosis of B Lymphocytes

IMMUNOLOGIC evaluation of lymphocytes from peripheral blood or other tissues in a patient with a lymphoproliferative disorder may be helpful in establishing the benign or malignant nature of the process. In this regard, the ability to document monoclonal B cells by immunoglobulin-light-chain typing...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 307; no. 4; pp. 232 - 236
Main Authors Gordon, David S, Jones, Bonnie M, Browning, Sandra W, Spira, Thomas J, Lawrence, Dale N
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 22.07.1982
Subjects
Adult
Antigens
B-Lymphocytes - immunology
Bacterial infections
Case reports
Disease control
Female
HLA Antigens - analysis
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Immunoglobulins
Infectious diseases
Laboratories
Lymphatic system
Lymphocytes
Lymphocytes B
Lymphocytosis
Lymphocytosis - immunology
Lymphoproliferative Disorders - immunology
Microscopy
Middle Aged
Patients
Pneumonia
Receptors, Antigen, B-Cell - analysis
Rosette Formation
Transplants & implants
Viral infections
Viruses
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Summary:IMMUNOLOGIC evaluation of lymphocytes from peripheral blood or other tissues in a patient with a lymphoproliferative disorder may be helpful in establishing the benign or malignant nature of the process. In this regard, the ability to document monoclonal B cells by immunoglobulin-light-chain typing in a lymphoproliferative process is strong evidence of the presence of neoplasia. 1 2 3 4 5 6 7 Our own experience has been that most patients with chronic peripheral lymphocytosis have an underlying monoclonal malignant proliferation. Recently, however, we evaluated three patients who appeared to have had a unique stable lymphoproliferative disease for as long as 15 years. Several singular clinical and laboratory . . .
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198207223070407