Putting Two Heads Together to Unwind DNA

The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2–7 replicative helicase encircles double-st...

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Bibliographic Details
Published inCell Vol. 139; no. 4; pp. 652 - 654
Main Authors Takara, Thomas J., Bell, Stephen P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 13.11.2009
Subjects
Chromosomal Proteins, Non-Histone - metabolism
DNA - metabolism
DNA Helicases - metabolism
DNA Replication
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - metabolism
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Summary:The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2–7 replicative helicase encircles double-stranded DNA as head-to-head double hexamers.
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.10.037