Nasal cavity paraganglioma with malignant transformation: A case report

• Published in: Auris, nasus, larynx Vol. 35; no. 1; pp. 137 - 139
• Main Authors: Jin, Hong-Ryul, Lee, Ok-Jun, Ahn, Youngjin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.03.2008
• Subjects: Adult; Biomarkers, Tumor - analysis; Cell Transformation, Neoplastic - pathology; Diagnosis, Differential; Endoscopy; Epistaxis - etiology; Ewing's sarcoma; Female; Humans; Nasal cavity; Nasal Cavity - pathology; Nasal Cavity - surgery; Neuroectodermal Tumors, Primitive - pathology; Neuroectodermal Tumors, Primitive - surgery; Nose Neoplasms - pathology; Nose Neoplasms - surgery; Otolaryngology; Paraganglioma; Paraganglioma - pathology; Paraganglioma - surgery; PNET; S100 Proteins - analysis; Sarcoma, Ewing - pathology; Sarcoma, Ewing - surgery; Turbinates - pathology; Turbinates - surgery; Paraganglioma; PNET; Nasal cavity; Ewing's sarcoma
• ISSN: 0385-8146; 1879-1476
• DOI: 10.1016/j.anl.2007.05.009

Abstract Background In this report, we describe a young woman with a nasal cavity paraganglioma with malignant transformation. Methods and results A 23-year-old woman presented with frequent right-sided epistaxis. Physical examination revealed a pedunculated mass originating from the right superior turbinate and filling the posterior nasal cavity. The endoscopically removed mass was composed of a reddish anterior portion and a white, flesh-looking posterior portion, the latter comprising the majority of the tumor. Histologically, the anterior portion showed a paraganglioma and the posterior portion showed a separate malignant lesion simulating Ewing's sarcoma/PNET. She underwent wide endoscopic excision including the site of tumor origin and has been followed up for 3 years without any evidence of disease recurrence. Conclusion This is a rare case of nasal cavity paraganglioma that had transformed into a malignant tumor.