Molecular mechanisms of chemoresistance in gastric cancer

Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide.Chemotherapy is one of the major treatments for gastric cancer,but drug resistance limits the effectiveness of chemotherapy,which results in treatment failure.Resistance to chemotherapy can be pre...

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Bibliographic Details
Published inWorld journal of gastrointestinal oncology Vol. 8; no. 9; pp. 673 - 681
Main Authors Shi, Wen-Jia, Gao, Jin-Bo
Format Journal Article
LanguageEnglish
Published China Baishideng Publishing Group Inc 15.09.2016
Subjects
cancer;Chemotherapy
Drug
resistance;Gastric
Review
Drug resistance
Gastric cancer
Chemotherapy
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Summary:Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide.Chemotherapy is one of the major treatments for gastric cancer,but drug resistance limits the effectiveness of chemotherapy,which results in treatment failure.Resistance to chemotherapy can be present intrinsically before the administration of chemotherapy or it can develop during chemotherapy.The mechanisms of chemotherapy resistance in gastric cancer are complex and multifactorial.A variety of factors have been demonstrated to be involved in chemoresistance,including the reduced intracellular concentrations of drugs,alterations in drug targets,the dysregulation of cell survival and death signaling pathways,and interactions between cancer cells and the tumor microenvironment.This review focuses on the molecular mechanisms of chemoresistance in gastric cancer and on recent studies that have sought to overcome the underlying mechanisms of chemoresistance.
Bibliography:Wen-Jia Shi;Jin-Bo Gao;Department of Pediatric Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology;Department of Gastrointestinal Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology
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Supported by National Natural Science Foundation of China, No. 81572411.
Author contributions: Shi WJ and Gao JB contributed equally to this work.
Telephone: +86-27-85351619 Fax: +86-27-85351619
Correspondence to: Dr. Jin-Bo Gao, Associate Professor, Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. gaojinbo@163.com
ISSN:1948-5204
1948-5204
DOI:10.4251/wjgo.v8.i9.673