An amuse-bouche of stem cell regulation: Underlying principles and mechanisms from adult Drosophila intestinal stem cells

Stem cells have essential functions in the development and maintenance of our organs. Improper regulation of adult stem cells and tissue homeostasis can result in cancers and age-dependent decline. Therefore, understanding how tissue-specific stem cells can accurately renew tissues is an important a...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 73; pp. 58 - 68
Main Authors Boumard, Benjamin, Bardin, Allison J.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2021
Elsevier
Subjects
Adult Stem Cells
Animals
Drosophila
Drosophila melanogaster
Homeostasis
Intestines
Life Sciences
Models, Biological
Stem Cells
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Summary:Stem cells have essential functions in the development and maintenance of our organs. Improper regulation of adult stem cells and tissue homeostasis can result in cancers and age-dependent decline. Therefore, understanding how tissue-specific stem cells can accurately renew tissues is an important aim of regenerative medicine. The Drosophila midgut harbors multipotent adult stem cells that are essential to renew the gut in homeostatic conditions and upon stress-induced regeneration. It is now a widely used model system to decipher regulatory mechanisms of stem cell biology. Here, we review recent findings on how adult intestinal stem cells differentiate, interact with their environment, and change during aging.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2021.05.007