An In-Vitro Study for Early Detection and to Distinguish Breast and Lung Malignancies Using the Pcb Technology Based Nanodosimeter

• Published in: Scientific reports Vol. 9; no. 1; p. 380
• Main Authors: Venkatraman, P, Sureka, C S
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 23.01.2019; Nature Publishing Group UK
• Subjects: Adult; Aged; Biopsy; Breast; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - metabolism; Cancer; Early Diagnosis; Female; Gas chromatography; Gas Chromatography-Mass Spectrometry; Humans; Ionization; Ions; Lung cancer; Lung Neoplasms - diagnosis; Lung Neoplasms - metabolism; Lungs; Malignancy; Mass spectroscopy; Middle Aged; Nanotechnology; Organic compounds; PCB; Polychlorinated biphenyls; Sensors; VOCs; Volatile organic compounds; Volatile Organic Compounds - analysis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-36805-2

Since the early detection of cancer increases the chance of successful treatment, the present study focused to confirm the suitability of an indigenously fabricated multilayer PCB technology based 3D positive ion detector to detect breast and lung malignancy at an early stage. The 3D positive ion detector is a type of gas filled radiation detector works under the principle of ion induced ionization using an exempted micro curie activity source. Earlier studies report that malignant cells can be detected by analyzing the Volatile Organic Compounds (VOCs) exhaled by those cells that serve as eminent biomarkers for malignant detection. Based on this, the present study analyzed the signals produced in the detector by VOCs exhaled from 140 biopsy tissue samples that include tissue of normal and all stages of breast and lung malignancy. To strengthen the present data, the normal and advanced breast and lung malignant tissues were also analyzed using the Gas Chromatography- Mass Spectrometry (GC-MS). From this study, it is confirmed that the present 3D positive ion detector can be used to detect both breast and lung malignancy and also to distinguish them based on the variation in four basic physical parameters of the output pulse such as frequency, amplitude, rise time and fall time and four derived parameters of the pulse such as FWHM, area of the pulse, ionization cluster size, and ion drift time.