Aphasia, neglect and extinction are no prominent clinical signs in children and adolescents with acute surgical cerebellar lesions

• Published in: Experimental brain research Vol. 184; no. 4; pp. 511 - 519
• Main Authors: Frank, Benedikt, Schoch, Beate, Hein-Kropp, Christoph, Hövel, Matthias, Gizewski, Elke Ruth, Karnath, Hans-Otto, Timmann, Dagmar
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2008; Springer; Springer Nature B.V
• Subjects: Acute Disease; Adolescent; Aphasia; Aphasia - diagnosis; Aphasia - etiology; Ataxia; Attention deficit disorders. Hyperactivity; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Bone surgery; Brain cancer; Brain research; Cerebellar Neoplasms - pathology; Cerebellar Neoplasms - surgery; Chemotherapy; Child; Child clinical studies; Cognition; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Extinction, Psychological; Female; Functional Laterality; Humans; Language; Language Disorders - diagnosis; Language Disorders - etiology; Magnetic Resonance Imaging; Male; Medical sciences; Movement Disorders - diagnosis; Movement Disorders - etiology; Nervous system (semeiology, syndromes); Neurology; Neurosciences; Orthopedics; Perceptual Disorders - diagnosis; Perceptual Disorders - etiology; Postoperative Complications - diagnosis; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radiation; Research Article; Speech; Teenagers; Tumors; Germany; Cerebellum; Visuospatial; Cognition; Language; Non-motor; Human; Nervous system diseases; Magnetic resonance; Central nervous system; Right hemisphere; Language disorder; Encephalon; Cerebral disorder; Communication disorder; Attentional disorder; Left hemisphere; Central nervous system disease; Adolescent; Aphasia; Neurological disorder
• ISSN: 0014-4819; 1432-1106
• DOI: 10.1007/s00221-007-1116-8

The aim of the present study was to examine if clinically significant signs of aphasia, neglect or extinction, which have a well-known cerebral lateralization, are present in children and adolescents with acute focal lesions following tumour surgery in the cerebellum. Eight children and adolescents with cerebellar tumours were tested within days after tumour surgery. None of the children had received radiation or chemotherapy at the time of testing. Eleven age- and education-matched control subjects with major orthopedic surgery participated. High-resolution magnetic resonance images showed lesions of the right cerebellar hemisphere in three and of the left hemisphere in five children. Standard aphasia tests revealed no statistically significant difference comparing children with right- and left-sided lesions and controls. Mild signs of language disturbance, however, were present in single subjects with right-sided cerebellar lesions. Neglect and extinction tasks revealed minor abnormalities, which lacked consistent lateralization and were best explained by more unspecific attentional deficits and motor disorders in acute post-surgical stage. Acute right-sided cerebellar lesions can be followed by mild signs of language disturbances in single subjects. Clinically significant signs of neglect and extinction, however, are not observed in children and adolescents with acute surgical cerebellar lesions.