Inhibition of Na,K-ATPase by sodium selenite and reversal by glutathione

Sodium selenite has been shown to inhibit Na,K-ATPase. Glutathione, at sufficient excess, is able to prevent or reverse the inhibition. Dithiothreitol can also reverse much of the inhibition, but KCN cannot. Selenomethionine does not inhibit Na,K-ATPase. The interactions of sodium selenite with Na,K...

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Bibliographic Details
Published inCurrent eye research Vol. 5; no. 12; p. 919
Main Authors Bergad, P L, Rathbun, W B
Format Journal Article
LanguageEnglish
Published England 1986
Subjects
Animals
Dogs
Glutathione - pharmacology
Selenious Acid
Selenium - pharmacology
Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
Sodium-Potassium-Exchanging ATPase - metabolism
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Summary:Sodium selenite has been shown to inhibit Na,K-ATPase. Glutathione, at sufficient excess, is able to prevent or reverse the inhibition. Dithiothreitol can also reverse much of the inhibition, but KCN cannot. Selenomethionine does not inhibit Na,K-ATPase. The interactions of sodium selenite with Na,K-ATPase and glutathione may aid in understanding the early events in selenium cataractogenesis.
ISSN:0271-3683
DOI:10.3109/02713688608995172