The use of intracytoplasmic sperm injection with electroejaculates from anejaculatory men

• Published in: Human reproduction (Oxford) Vol. 13; no. 7; pp. 1854 - 1858
• Main Authors: Chung, P H, Palermo, G, Schlegel, P N, Veeck, L L, Eid, J F, Rosenwaks, Z
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.1998
• Subjects: Biological and medical sciences; Birth control; Ejaculation; Electric Stimulation; Embryo Transfer; Female; Fertilization in Vitro - methods; Gynecology. Andrology. Obstetrics; Humans; Infertility, Male - etiology; Infertility, Male - therapy; Lymph Node Excision - adverse effects; Male; Medical sciences; Microinjections; Pregnancy; Sexual Dysfunction, Physiological - etiology; Spinal Cord Injuries - complications; Sterility. Assisted procreation; Testicular Neoplasms - complications; In vitro fertilization embryo transfer; Human; Electroejaculation; Prognosis; Ejaculation disorders; Intracytoplasmic sperm injection; Assisted procreation; Male; Anejaculation; Male genital diseases
• ISSN: 0268-1161; 1460-2350
• DOI: 10.1093/humrep/13.7.1854

Electroejaculation has been successfully used for sperm procurement in anejaculatory men desiring fertility. However, electroejaculates typically have normal sperm numbers but poor motility, morphology, and functional deficiencies. Here we report the pregnancy outcome of a series of couples undergoing combined electroejaculation and in-vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). In all, 13 couples underwent a total of 18 cycles. The aetiologies of anejaculation included history of retroperitoneal lymph node dissection for testicular cancers, spinal cord injury and psychogenic causes. ICSI was performed on 192 oocytes, resulting in a fertilization rate of 75.5%. A total of 15 embryo transfers were performed using a total of 51 embryos. Clinical pregnancy rate, as defined by positive fetal heart rate(s) using vaginal sonography, was 55.6% per retrieval; implantation rate was 33.3% per embryo. These rates appear to be similar to those obtained in standard IVF for non-male factor infertility, or ICSI for male factor infertility. The use of ICSI for electroejaculates undoubtedly provides these couples with the highest chance of pregnancy.