IgE and IgG Anti-Thyroid Autoantibodies in Chinese Patients With Chronic Spontaneous Urticaria and a Literature Review

• Published in: Allergy, asthma & immunology research Vol. 14; no. 1; pp. 131 - 142
• Main Authors: Zhang, Liming, Qiu, Li, Wu, Jian, Qi, Yumeng, Wang, Hexiao, Qi, Ruiqun, Yao, Xu, Zhu, Hong, Li, Yuzhen, Hao, Siyu, Lu, Qianjin, Long, Hai, Lian, Shi, Zhang, Haiping, Zhu, Wei, Lai, Wei, Su, Xiangyang, Lu, Rongbiao, Guo, Zaipei, Li, Jingyi, Li, Mengmeng, Liu, Quanzhong, Wang, Huiping, He, Li, Nong, Xiang, Li, Fuqiu, Li, Yang, Yao, Chunli, Xu, Jinhua, Tang, Hui, Wang, Duoqin, Li, Zhenlu, Yu, Huiqian, Xiao, Shengxiang, An, Jingang, Pu, Xiongming, Yu, Shirong, Zhang, Jianzhong, Chen, Xue, Gao, Xinghua, Chen, Hongduo, Xiao, Ting
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Academy of Asthma, Allergy and Clinical Immunology 01.01.2022; The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
• Subjects: Antihistamines; Autoantibodies; Brief Communication; Chemiluminescence; Enzyme-linked immunosorbent assay; Immunoassay; Immunoblotting; Immunoglobulin E; Immunoglobulin G; Immunopathogenesis; Iodide peroxidase; Literature reviews; Microparticles; Minority & ethnic groups; Patients; Peroxidase; Thyroglobulin; Thyroid; Thyroid gland; Urticaria; thyroid peroxidase; Chronic spontaneous urticaria; thyroglobulin; immunoglobulin E
• ISSN: 2092-7355; 2092-7363
• DOI: 10.4168/aair.2022.14.1.131

Immunoglobulin (Ig) E and IgG anti-thyroid autoantibodies (AAbs) play important roles in the immunopathogenesis of chronic spontaneous urticaria (CSU). To date, association of IgE and IgG AAbs with Chinese CSU patients has not been fully investigated. We aimed to explore prevalence rates of IgE and IgG AAbs in Chinese CSU patients and their association with clinical and laboratory parameters. Serum IgE and IgG AAbs against thyroid peroxidase (TPO) and thyroglobulin (TG), total IgE (tIgE) and specific IgEs were measured using enzyme-linked immunosorbent assay, chemiluminescence microparticle immunoassay and immunoblotting. Meta-analyses and literature review were conducted. The meta-analyses indicated that CSU cases were 4.98, 6.90 and 6.68 times more likely to have positive anti-TPO IgE, anti-TPO IgG and anti-TG IgG (all < 0.001) compared with controls, respectively, and revealed a positive correlation between the prevalence rates of anti-TPO IgE and anti-TPO IgG ( = 0.53, = 0.025). A total of 1,100 Chinese Han adult CSU patients and 1,100 ethnicity-, age- and sex-matched healthy controls were recruited from 15 centers. Prevalence rates of anti-TPO IgE, anti-TPO IgG, anti-TG IgE or anti-TG IgG in the patients were all significantly higher than those in the controls. Significant correlations were observed between prevalence rates of anti-TPO IgE and anti-TPO IgG ( = 0.297, < 0.001) as well as between those of anti-TG IgE and anti-TG IgG in the patients ( = 0.137, < 0.001). Patients with anti-TPO IgE or anti-TPO IgG had significantly lower tIgE levels ( < 0.001). Positive anti-TPO IgE, positive anti-TPO IgG and tIgE < 40 IU/mL were independent predictors of antihistamine-refractory cases. In conclusion, the prevalence rates of IgE and IgG AAbs in Chinese CSU patients are significantly elevated and reciprocally correlated. This study verifies the results of previous case-control studies of CSU patients from other populations and ethnicities.