Adaptation of a quantitative trait to a changing environment: New analytical insights on the asexual and infinitesimal sexual models

• Published in: Theoretical population biology Vol. 152; pp. 1 - 22
• Main Authors: Garnier, J., Cotto, O., Bouin, E., Bourgeron, T., Lepoutre, T., Ronce, O., Calvez, V.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023; Elsevier
• Subjects: Adaptation, Biological; Biodiversity; Biological Evolution; Environment; Environmental changes; Genetics; Genetics, Population; Hamilton–Jacobi equations; Infinitesimal model; Life Sciences; Maladaptation; Models, Genetic; Phenotype; Populations and Evolution; Quantitative trait; Reproduction, Asexual; Environmental changes; Quantitative trait; Infinitesimal model; Hamilton–Jacobi equations; Maladaptation; Hamilton-Jacobi equations; maladaptation; environmental changes; quantitative trait
• ISSN: 0040-5809; 1096-0325
• DOI: 10.1016/j.tpb.2023.04.002

Predicting the adaptation of populations to a changing environment is crucial to assess the impact of human activities on biodiversity. Many theoretical studies have tackled this issue by modeling the evolution of quantitative traits subject to stabilizing selection around an optimal phenotype, whose value is shifted continuously through time. In this context, the population fate results from the equilibrium distribution of the trait, relative to the moving optimum. Such a distribution may vary with the shape of selection, the system of reproduction, the number of loci, the mutation kernel or their interactions. Here, we develop a methodology that provides quantitative measures of population maladaptation and potential of survival directly from the entire profile of the phenotypic distribution, without any a priori on its shape. We investigate two different systems of reproduction (asexual and infinitesimal sexual models of inheritance), with various forms of selection. In particular, we recover that fitness functions such that selection weakens away from the optimum lead to evolutionary tipping points, with an abrupt collapse of the population when the speed of environmental change is too high. Our unified framework allows deciphering the mechanisms that lead to this phenomenon. More generally, it allows discussing similarities and discrepancies between the two systems of reproduction, which are ultimately explained by different constraints on the evolution of the phenotypic variance. We demonstrate that the mean fitness in the population crucially depends on the shape of the selection function in the infinitesimal sexual model, in contrast with the asexual model. In the asexual model, we also investigate the effect of the mutation kernel and we show that kernels with higher kurtosis tend to reduce maladaptation and improve fitness, especially in fast changing environments. •Adaptation to a changing environment may generate non Normal phenotypic distribution.•The phenotypic variance at equilibrium truly depends on reproduction model.•Selection shapes mean fitness only in sexual infinitesimal model.•Weak selection away from the optimum may lead to evolutionary tipping points.•Frequent mutations with large effects reduce maladaptation and improve fitness.