Cyclobenzaprine overdosage

The clinical findings in three patients who ingested 260-900 mg cyclobenzaprine (Flexeril) consisted of delayed onset and long duration of anticholinergic symptomatology. In two of these patients, symptoms responded to treatment with physostigmine. The third patient recovered without specific therap...

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Bibliographic Details
Published inJournal of toxicology. Clinical toxicology Vol. 20; no. 3; p. 281
Main Authors Linden, C H, Mitchiner, J C, Lindzon, R D, Rumack, B H
Format Journal Article
LanguageEnglish
Published United States 01.01.1983
Subjects
Adolescent
Adult
Amitriptyline - analogs & derivatives
Amitriptyline - poisoning
Female
Humans
Male
Physostigmine - therapeutic use
Suicide, Attempted
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Summary:The clinical findings in three patients who ingested 260-900 mg cyclobenzaprine (Flexeril) consisted of delayed onset and long duration of anticholinergic symptomatology. In two of these patients, symptoms responded to treatment with physostigmine. The third patient recovered without specific therapy. Despite its structural similarity to amitriptyline, cyclobenzaprine overdosage did not result in coma, seizures, or cardiac toxicity. The pharmacological properties of cyclobenzaprine may account for the observed toxicity.
ISSN:0731-3810
DOI:10.3109/15563658308990071