Electronic considerations in the mutagenesis of some 4,5-bridged chrysenes

The mutagenic activity of four 4,5-bridged chrysene derivatives, benz(a)aceanthrylene, and 5-methylchrysene was examined using histidine auxotrophic strains TA98 and TA100 of Salmonella typhimurium. All compounds showed a positive mutagenic response with both TA100 and TA98 in the presence of S-9. A...

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Bibliographic Details
Published inEnvironmental mutagenesis Vol. 9; no. 2; p. 183
Main Authors Lee-Ruff, E, Raj, A S, Kruk, H, Katz, M
Format Journal Article
LanguageEnglish
Published United States 1987
Subjects
Biotransformation
Chemical Phenomena
Chemistry, Physical
Chrysenes - chemical synthesis
Chrysenes - toxicity
Microsomes, Liver - metabolism
Mutagenicity Tests
Phenanthrenes - toxicity
Salmonella typhimurium - drug effects
Structure-Activity Relationship
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Summary:The mutagenic activity of four 4,5-bridged chrysene derivatives, benz(a)aceanthrylene, and 5-methylchrysene was examined using histidine auxotrophic strains TA98 and TA100 of Salmonella typhimurium. All compounds showed a positive mutagenic response with both TA100 and TA98 in the presence of S-9. A correlation between the electronic character of the bridging group and mutagenic activity for the chrysene derivatives is proposed.
ISSN:0192-2521
DOI:10.1002/em.2860090209