UREA SECRETION INTO THE COLON OF SHEEP AND GOAT

Total urea entry rate into the body pool and urea hydrolysis rate (transfer of endogenous urea into the total gastrointestinal (g.i.) tract) were obtained after single intravenous injections of [ 14 C]urea and from renal urea excretion in sheep and goat. Secretion of endogenous urea into the colon w...

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Bibliographic Details
Published inExperimental physiology Vol. 69; no. 3; pp. 469 - 475
Main Authors Engelhardt, W. v., Hinderer, S., Rechkemmer, G., Becker, G.
Format Journal Article
LanguageEnglish
Published England The Physiological Society 16.07.1984
Subjects
Animals
Colon - metabolism
Female
Goats - metabolism
Hydrolysis
Male
Perfusion
Sheep - metabolism
Urea - blood
Urea - secretion
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Summary:Total urea entry rate into the body pool and urea hydrolysis rate (transfer of endogenous urea into the total gastrointestinal (g.i.) tract) were obtained after single intravenous injections of [ 14 C]urea and from renal urea excretion in sheep and goat. Secretion of endogenous urea into the colon was estimated from the appearance of urea N in the temporarily isolated and perfused colon. Rate of urea secretion ino the colon was rather small (0·10-0·31 mmol. h -1 ). It was only 0·3-1·1% of urea entry rate, or 0·4-7% of urea hydrolysis rate. Urea secretion into the colon increased linearly with increase of plasma urea concentration. Dietary conditions and short-chain fatty acid concentrations in colonic contents had no significant effect on the permeability of the colonic epithelium for urea.
ISSN:0958-0670
0144-8757
1469-445X
DOI:10.1113/expphysiol.1984.sp002833