Protein phosphorylation: A potential target in glioma development

• Published in: Ibrain Vol. 8; no. 2; pp. 176 - 189
• Main Authors: Pi, Yu, Fang, Chang‐Le, Su, Zhang‐Yu
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2022; John Wiley and Sons Inc; Wiley-VCH
• Subjects: Brain cancer; Cell cycle; Cell division; Cell growth; Chemotherapy; glioblastoma (GBM); Glioma; Impact factors; invasion; Kinases; Medical prognosis; Phosphorylation; proliferation; Proteins; Regulation; Review; Reviews; Stem cells; Tumorigenesis; glioblastoma (GBM); glioma; invasion; proliferation; phosphorylation
• ISSN: 2769-2795; 2313-1934; 2769-2795
• DOI: 10.1002/ibra.12038

Glioma is one of the most common primary brain tumors, and mortality due to this disease is second only to cardiovascular and cerebrovascular diseases. In traditional surgery, it is difficult to eradicate glioma; often recurrence increases its malignant degree, leading to a large number of patients killed by this disease. It is one of the most important subjects to study its pathogenesis and explore effective treatment methods. Research on glioma mechanisms mainly focuses on the effect of DNA methylation in epigenetics. Although there are many studies on protein phosphorylation, there is no overall regulatory mechanism. Protein phosphorylation regulates a variety of cell functions, such as cell growth, division and differentiation, and apoptosis. As a consequence, protein phosphorylation plays a leading part in various activities of glioma, and can also be used as a target to regulate the development of glioma. This review is aimed at studying the effect of protein phosphorylation on glioma, understanding the pathological mechanism, and an in‐depth analysis of it. The following is a discussion on glioma growth, migration and invasion, resistance and death in phosphorylation, and the possibility of treating glioma by phosphorylation. Glioma is a common primary brain tumor, and its mortality rate is extremely high. Protein phosphorylation regulates a number of cellular functions like cell growth, differentiation, apoptosis, and cell signaling, so it can also be used as a target to regulate the development of glioma. This review is a discussion on the growth, migration and invasion, resistance, and death of glioma in phosphorylation and the possibility of treating glioma by phosphorylation.