Inhibition of monoamine oxidase by 7-chloro-4-nitrobenzofurazan

• Published in: Journal of neurochemistry Vol. 55; no. 3; p. 813
• Main Authors: Fu, R C, Liu, X F, Chen, S U
• Format: Journal Article
• Language: English
• Published: England 01.09.1990
• Subjects: Animals; Benzofurans - pharmacology; Binding, Competitive; Brain - enzymology; Cattle; Female; Hydrogen-Ion Concentration; Kinetics; Mitochondria - enzymology; Mitochondria, Liver - enzymology; Monoamine Oxidase Inhibitors - pharmacology; Placenta - enzymology; Placenta - ultrastructure; Pregnancy; Rats

7-Chloro-4-nitrobenzofurazan (NBD-Cl) is a potent inhibitor of both types of monoamine oxidase (MAO). NBD-Cl competitively inhibited the oxidative deamination of kynuramine catalyzed by human placenta MAO-A, the oxidative deamination of benzylamine catalyzed by bovine liver MAO-B, the oxidative deam...