Transforming Growth Factor Beta (TGF-β) Gene Family Members in Developing and Neoplastic Odontogenic Tissues

During the last decade, several molecules regulating tooth development have been identified (http://bite-it.helsinki.fi/). Especially members of the transforming growth factor beta (TGF-β) supergene family, structurally relates cytokines, are essential for teeth to develop. These include TGF-βs, act...

Full description

Saved in:
Bibliographic Details
Published inJournal of Hard Tissue Biology Vol. 15; no. 1; pp. 1 - 5
Main Authors Heikinheimo, Kristiina, Mori, Kazuhisa, Nagatsuka, Hitoshi, Happonen, Risto-Pekka
Format Journal Article
LanguageEnglish
Japanese
Published THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY 01.01.2006
The Society for Hard Tissue Regenerative Biology
Subjects
Activin
BMP
Follistatin
Odontogenesis
Odontogenic tumour
TGF-β receptor
Online AccessGet full text

Cover

More Information
Summary:During the last decade, several molecules regulating tooth development have been identified (http://bite-it.helsinki.fi/). Especially members of the transforming growth factor beta (TGF-β) supergene family, structurally relates cytokines, are essential for teeth to develop. These include TGF-βs, activin A, bone morphogenetic proteins (BMPs), and their cell surface receptors. In addition, follistatin, an extracellular protein that interacts with activin and BMP signalling, appears to be an important mediator of associated inductive signals. Enhanced or impaired TGF-β/BMP signalling may play a role in odontogenic tumorigenesis. This review focuses on findings of our studies on the roles played by of TGF-β receptors, their ligands and extracellular modifiers during tooth development and in odontogenic tumours.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1341-7649
1880-828X
DOI:10.2485/jhtb.15.1