A compendium on single‐cell analysis for the curious

• Published in: The FEBS journal Vol. 286; no. 8; pp. 1442 - 1444
• Main Authors: Gallant, Caroline J., Landegren, Ulf
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.04.2019
• Subjects: Computational Biology - methods; Diagnostic systems; High-Throughput Screening Assays - methods; High-Throughput Screening Assays - statistics & numerical data; Humans; Microscopy - methods; Proteomics - methods; Single-Cell Analysis - methods; Single-Cell Analysis - statistics & numerical data
• ISSN: 1742-464X; 1742-4658; 1742-4658
• DOI: 10.1111/febs.14820

Single‐cell analysis is impacting biology and medicine by changing the scale and resolution at which we investigate multicellular organisms. A particular, overarching aim of this field is to characterize the programmed development of all different cell types in the human body, as well as their individual spatial, molecular, and functional characteristics. This vast research program is generating a much‐needed source of fundamental biological insights that will provide a basis for new diagnostic and therapeutic approaches. With this Focus Issue on Single‐Cell Analyses, The FEBS Journal offers interested readers an excellent introduction to this exciting research field, including ideas on how a wide community can benefit from the powerful approaches and technologies as well as the biological knowledge generated. A special Focus Issue on Single‐Cell Analyses is introduced by Guest Editors Caroline Gallant and Ulf Landegren. The issue contains six reviews that highlight recent technological advances, insights into biomedicine gained and potential future applications of single‐cell biology. The issue also includes an interview with Sarah Teichmann, a pioneer in single‐cell techniques. We hope that these unique contributions from leading scientists in the field will engage and inform interested readers.