Non-infectious granulomatous disorders of the upper lip: clinicopathological analysis of 11 patients

• Published in: BMC oral health Vol. 22; no. 1; pp. 173 - 8
• Main Authors: Lafuente-Ibáñez de Mendoza, Irene, Vigarios, Emmanuelle, Herbault-Barres, Béatrice, Alberdi-Navarro, Javier, Sibaud, Vincent, Maret, Delphine, Aguirre-Urizar, José Manuel
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.05.2022; BioMed Central; BMC
• Subjects: Adult; Aged; Aged, 80 and over; Biopsy; Case reports; Crohn's disease; Development and progression; Diagnosis, Differential; Differential diagnosis; Diseases; Enzymes; Erythema; Exocrine glands; Female; Foreign bodies; France; Gingivitis; Gingivitis - etiology; Granuloma; Granulomas; Humans; Hydroxyapatite; Infectious diseases; Laboratories; Lichen; Lip; Lips; Male; Maxillofacial; Middle Aged; Mouth Mucosa; Mucositis; Pathology; Patients; Physiological aspects; Sarcoidosis; Systemic; Upper lip; Womens health; France; Granuloma; Systemic; Upper lip; Lichen; Foreign bodies
• ISSN: 1472-6831; 1472-6831
• DOI: 10.1186/s12903-022-02189-z

Non-infectious granulomatous disorders of the upper lip represent a special chapter of oral and maxillofacial pathology. In this work we report a case-series of this process, to analyse its main clinicopathological features and find differential data that allow us improve its diagnosis and understand its pathogenesis. We present 11 cases of non-infectious granulomatous disorders of the upper lip, 8 women and 3 men with an age range of 29-84 years, who have been attended at the Oral Medicine Department of the IUCT (France) and the Oral Medicine Unit of the UPV/EHU (Spain). All clinicopathological data were collected in a specific protocol. We recognized 4 different subtypes of non-infectious granulomatous disorders of the upper lip: (1) associated with Crohn's disease (1 case), (2) associated with foreign body (2 cases), (3) associated with gingivitis lichenoid-like (4 cases), (4) idiopathic (4 cases). Clinicopathological differences were identified between these subtypes. A good differential diagnosis is necessary in all cases to rule out the presence of local or systemic etiopathogenic factors.