Cytokine and viral load kinetics in human herpesvirus 8-associated multicentric Castleman’s disease complicated by hemophagocytic lymphohistiocytosis

• Published in: International journal of hematology Vol. 103; no. 4; pp. 469 - 472
• Main Authors: Zondag, Timo C. E., Rokx, Casper, van Lom, Kirsten, van den Berg, Arjan R., Sonneveld, Pieter, Dik, Willem A., van Doornum, Gerard J. J., Lam, King H., van Laar, Jan A. M.
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.04.2016; Springer Nature B.V
• Subjects: Case Report; Castleman Disease - blood; Castleman Disease - complications; Castleman Disease - pathology; Castleman Disease - virology; Female; Hematology; Herpesviridae Infections - blood; Herpesviridae Infections - complications; Herpesviridae Infections - pathology; Herpesviridae Infections - virology; Herpesvirus; Herpesvirus 8, Human - physiology; Human herpesvirus 8; Human immunodeficiency virus; Humans; Interleukin-10 - blood; Lymph Nodes - pathology; Lymph Nodes - virology; Lymphohistiocytosis, Hemophagocytic - blood; Lymphohistiocytosis, Hemophagocytic - complications; Lymphohistiocytosis, Hemophagocytic - pathology; Lymphohistiocytosis, Hemophagocytic - virology; Medicine; Medicine & Public Health; Middle Aged; Oncology; Viral Load; Hemophagocytic lymphohistiocytosis; Human herpes virus 8; Interleukin-10; Multicentric Castleman’s disease
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-015-1928-4

Human herpes virus 8 (HHV-8)-associated secondary hemophagocytic lymphohistiocytosis is a rare but critical immuno-hematological entity in immunocompetent patients. Establishing a diagnosis is challenging as is the monitoring of disease activity and therapeutic effects. We report a case of a HHV-8-associated hemophagocytic lymphohistiocytosis in a HIV-negative adult patient with multicentric Castleman’s disease. As a novel finding, we report the use of certain inflammatory parameters, primarily interleukin-10 combined with viral load monitoring of the causative infectious agent in this case HHV-8 to monitor the clinical course of the hemophagocytic lymphohistiocytosis in the setting of bacterial septic complications.