Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues

• Published in: Chemical science (Cambridge) Vol. 14; no. 29; pp. 7782 - 7817
• Main Authors: Zhang, Shengping, De Leon Rodriguez, Luis M, Li, Freda F, Brimble, Margaret A
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 26.07.2023; The Royal Society of Chemistry
• Subjects: Chemistry; Cleavage; Conjugation; Lysine; Medical materials; Peptides; Proteins; Residues; Tyrosine
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/d3sc02543h

Peptide and protein selective modification at tyrosine residues has become an exploding field of research as tyrosine constitutes a robust alternative to lysine and cysteine-targeted traditional peptide/protein modification protocols. This review offers a comprehensive summary of the latest advances in tyrosine-selective cleavage, functionalization, and conjugation of peptides and proteins from the past three years. This updated overview complements the extensive body of work on site-selective modification of peptides and proteins, which holds significant relevance across various disciplines, including chemical, biological, medical, and material sciences. This review covers recent progress in tyrosine-selective cleavage, functionalization, and conjugation of peptides and proteins. Key applications of Tyr modification are highlighted, demonstrating its great potential for chemistry and biology.