Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides

• Published in: Actanaturae Vol. 10; no. 4; pp. 125 - 128
• Main Authors: Palikov, V A, Terekhov, S S, Palikova, Yu A, Khokhlova, O N, Kazakov, V A, Dyachenko, I A, Panteleev, S V, Mokrushina, Yu A, Knorre, V D, Shamborant, O G, Smirnov, I V, Gabibov, A G
• Format: Journal Article
• Language: English
• Published: Russia (Federation) A.I. Gordeyev 01.10.2018
• Subjects: in vivo model; bioscavenger; butyrylcholinesterase; organophosphorus toxins
• ISSN: 2075-8251
• DOI: 10.32607/20758251-2018-10-4-125-128

The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. The study showed a high activity of BChE as a protective agent for subchronic anticholinesterase poisoning in an model. The administration of BChE in a dose of 20 mg / kg allows one to avoid mortality, and also contributed to rapid recovery after model poisoning.