Developments in metabolic engineering

The complete sequencing of several microbial genomes has resulted in the increased availability of genes for metabolic engineering. The number of databases and computational tools to deal with this information has also increased. This development has stimulated, and will continue to stimulate, advan...

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Bibliographic Details
Published inCurrent opinion in biotechnology Vol. 8; no. 2; pp. 175 - 180
Main Authors Cameron, Douglas C, Chaplen, Frank WR
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.1997
Subjects
MFA metabolic flux analysis
CHO Chinese hamster ovary
VHb Vitreoscilla hemoglobin
DAHP 3-deoxy- d-arabino-heptulosonate 7-phosphate
PEP phosphoenolpyruvate
MCA metabolic control analysis
PHB polyhydroxybutyrate
BST biochemical systems theory
PTS phosphotransferase system
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Summary:The complete sequencing of several microbial genomes has resulted in the increased availability of genes for metabolic engineering. The number of databases and computational tools to deal with this information has also increased. This development has stimulated, and will continue to stimulate, advances in metabolic engineering. Specific recent advances include improvement of pathways for aromatic metabolites, the development of a more complete understanding of the effect of bacterial hemoglobin on cell performance, the development of NMR-based methods for the monitoring of intracellular metabolites and metabolic flux, and the application of metabolic control analysis and metabolic flux analysis to a variety of systems.
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ISSN:0958-1669
1879-0429
DOI:10.1016/S0958-1669(97)80098-5