Phytochemical analysis of Gymnema sylvestre and evaluation of its antimicrobial activity

• Published in: Natural product research Vol. 27; no. 6; pp. 583 - 587
• Main Authors: Chodisetti, Bhuvaneswari, Rao, Kiranmayee, Giri, Archana
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.03.2013
• Subjects: acetone; Alkanes - chemistry; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; anti-infective properties; antimicrobial activity; Bacteria - drug effects; chloroform; ethyl ether; G. sylvestre; Gas Chromatography-Mass Spectrometry; GC-MS; Gymnema sylvestre; Gymnema sylvestre - chemistry; MIC; minimum inhibitory concentration; oleic acid; Oleic Acid - chemistry; pathogens; Plant Components, Aerial - chemistry; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Roots - chemistry; root extracts; saponins; stigmasterol; Stigmasterol - chemistry; vitamin E; Vitamin E - chemistry
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2012.676548

Gymnema sylvestre (CS 149), known to be a rich source of saponins and other valuable phytochemicals, has been analysed for antimicrobial activity. The chloroform extracts of aerial and root parts of G. sylvestre exhibited higher antimicrobial activity as compared to diethyl ether and acetone. The root extracts of chloroform have shown competitive minimum inhibitory concentration and minimum bactericidal concentration values in the range of 0.04-1.28 mg mL −1 and 0.08-2.56 mg/mL, respectively, towards the pathogens. The GC-MS analysis of chloroform extracts has shown the presence of compounds like eicosane, oleic acid, stigmasterol and vitamin E.