A Crack in Histone Lysine Methylation

Histone lysine methylation is regarded as a very stable modification with important functions in epigenetic gene control and for organizing chromatin domains. While more robust modifications of the chromatin template are essential to stabilize epigenetic information, there is now the first evidence...

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Bibliographic Details
Published inCell Vol. 119; no. 7; pp. 903 - 906
Main Authors Kubicek, Stefan, Jenuwein, Thomas
Format Book Review Journal Article
LanguageEnglish
Published United States Elsevier Inc 29.12.2004
Subjects
Epigenesis, Genetic
Gene Silencing
Histones - metabolism
Lysine - metabolism
Methylation
Oxidoreductases, N-Demethylating - chemistry
Oxidoreductases, N-Demethylating - genetics
Oxidoreductases, N-Demethylating - metabolism
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Summary:Histone lysine methylation is regarded as a very stable modification with important functions in epigenetic gene control and for organizing chromatin domains. While more robust modifications of the chromatin template are essential to stabilize epigenetic information, there is now the first evidence for a histone lysine demethylase that reverts an activating methyl mark to the unmodified state (Shi et al., 2004 [this issue of Cell]).
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2004.12.006