Quadrantal macular retinal thickness changes in strabismus subjects with abnormal binocular vision development

• Published in: Japanese journal of ophthalmology Vol. 57; no. 2; pp. 225 - 232
• Main Authors: Oka, Mayumi, Yamashita, Tsutomu, Ono, Shizuka, Kubo, Ikumi, Tabuchi, Akio
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.03.2013; Springer Nature B.V
• Subjects: Adolescent; Adult; Clinical Investigation; Dominance, Ocular; Female; Humans; Male; Medicine; Medicine & Public Health; Ophthalmology; Organ Size; Retina - pathology; Retinal Diseases - diagnosis; Retinal Diseases - etiology; Retinal Ganglion Cells - pathology; Strabismus - complications; Tomography, Optical Coherence; Vision Disorders - complications; Vision, Binocular; Visual Acuity; Young Adult; Strabismus; Retinal macular thickness; Macular quadrant; Ganglion cell complex thickness; Abnormal binocular vision development
• ISSN: 0021-5155; 1613-2246; 1613-2246
• DOI: 10.1007/s10384-012-0214-8

Purpose To investigate retinal morphological changes in strabismus patients with abnormal binocular vision development by comparing differences in quadrantal macular retinal thickness. Methods Six strabismus patients (6 dominant and 5 non-dominant eyes) with abnormal binocular vision (mean age 22 years), and 11 control subjects (11 dominant and 11 non-dominant eyes) (mean age 21 years) were enrolled. Macular retinal thickness measurements were performed by optical coherence tomography, with total macular retinal (TMR) and ganglion cell complex (GCC) thicknesses measured in 3- and 6-mm regions in each quadrant. Measurement values were then used to determine quadrant ratios. Results Compared to the dominant eyes of the controls, the superior/inferior (S/I) ratio of the TMR thickness and GCC thickness in the 3-mm region was significantly lower in the dominant eyes of the strabismus group ( P  < 0.05, each). The superior temporal/inferior temporal (ST/IT) ratio of the GCC thickness in the dominant eyes of the strabismus group was also significantly lower ( P  < 0.01). Conclusions Dominant eyes of the strabismus group with abnormal binocular vision development exhibited thinner superior temporal GCC thicknesses in the 3-mm region. Retinal ganglion cells in this region might be affected by efferent neural degeneration that originates in the visual pathway responsible for adaptations to the visual experience.