Influence of caloric contribution and saturation of dietary fat on plasma lipids in premenopausal women

• Published in: The American journal of clinical nutrition Vol. 45; no. 6; pp. 1451 - 1456
• Main Authors: Jones, D Y, Judd, J T, Taylor, P R, Campbell, W S, Nair, P P
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.06.1987; American Society for Clinical Nutrition
• Subjects: Adult; ADULTOS; Age Factors; ASCORPS GRAS; Biological and medical sciences; Cholesterol - blood; Cholesterol, HDL - blood; DIETA; Dietary Fats - administration & dosage; Energy Intake; Fatty Acids, Unsaturated - administration & dosage; Female; FEMME; Fundamental and applied biological sciences. Psychology; GRASAS; Humans; LIPIDE; LIPIDOS; Lipids - blood; Lipids. Glycolipids; Menstrual Cycle; Metabolisms and neurohumoral controls; MUJERES; REGIME ALIMENTAIRE; SANG; SANGRE; Triglycerides - blood; VALEUR CALORIQUE; VALOR CALORICO; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; Deficient diet; Diet; Saturated fatty acid; Polyunsaturated fatty acid; Lipids; Supplemented diet; Woman; Metabolism; Triglyceride; Cholesterol
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/45.6.1451

Total cholesterol, HDL cholesterol, and triglycerides were measured in 31 premenopausal women randomized into one of two diet groups: one diet with a P:S ratio of 1.0 and one diet with a P:S ratio of 0.3. Both groups were fed a high-fat diet (40% of energy from fat) for four menstrual cycles per subject followed by a similar interval on a low-fat diet (20% of energy from fat). Changing from the high-fat to the low-fat diet resulted in a nonsignificant mean decrease of 7% in total cholesterol. HDL-cholesterol response to the low-fat regimen was influenced by the P:S ratio. Women in the high P:S group showed no change; mean HDL cholesterol in women in the low P:S group decreased 12%. Plasma triglycerides increased in both groups on the low-fat diet although the increase was greatest in the low P:S group.