Is gonorrhea becoming untreatable?

An estimated 498 million new cases of curable sexually transmitted infections occur worldwide annually. Of these, 106 million are gonococcal infections, rendering gonorrhea the second most prevalent bacterial sexually transmitted infection after chlamydia. A decline in susceptibility to extended-spe...

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Published inFuture microbiology Vol. 9; no. 2; pp. 189 - 201
Main Authors Blomquist, Paula Bianca, Miari, Victoria F, Biddulph, Jane P, Charalambous, Bambos M
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.02.2014
Subjects
Anti-Bacterial Agents - therapeutic use
antibiotic resistance
Antibiotics
Antimicrobial agents
Cephalosporin Resistance - genetics
Cephalosporins - therapeutic use
Drug resistance
Drug therapy
Forecasts and trends
Genes
Gonorrhea
Gonorrhea - diagnosis
Gonorrhea - drug therapy
Gonorrhea - epidemiology
Humans
Medical research
Mens health
Microbial drug resistance
Mutation
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - genetics
Neisseria gonorrhoeae - pathogenicity
Nucleic Acid Amplification Techniques
Patient education
Precision medicine
Public health
Risk assessment
Sex education
sexual behaviour
Sexually transmitted diseases
sexually transmitted infections
STD
STI
Streptococcus infections
Treatment Failure
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Summary:An estimated 498 million new cases of curable sexually transmitted infections occur worldwide annually. Of these, 106 million are gonococcal infections, rendering gonorrhea the second most prevalent bacterial sexually transmitted infection after chlamydia. A decline in susceptibility to extended-spectrum cephalosporins, as well as treatment failures, have been identified worldwide. This, together with the associated epidemiological and socioeconomic burden, is of increasing concern. Currently, the effectiveness of antibiotic resistance control measures is limited. Barriers include the lack of therapeutic options, the difficulties of reducing high-risk sexual behavior and propensity to rapidly acquire resistance determinants. While the disease remains treatable for the moment, we need to anticipate and be prepared for the arrival and spread of untreatable gonorrhea by using a multifaceted approach and search for other, perhaps novel control strategies.
Bibliography:ObjectType-Article-2
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ISSN:1746-0913
1746-0921
DOI:10.2217/fmb.13.155