Case Report: Infantile Bullous Pemphigoid: Triggering by COVID-19 Is Speculative

Bullous pemphigoid (BP) is a cutaneous disease triggered by numerous stimuli, where genetic milieu-influenced autoimmunity to hemidesmosomal proteins, namely, BP180 and/or BP230 initiate an inflammation leading to dermal-epidermal junction (DEJ) enzymatic pathological remodelling. Here, to the best...

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Published inFrontiers in medicine Vol. 8; p. 760823
Main Authors Rosińska-Więckowicz, Anna, Jałowska, Magdalena, Bowszyc-Dmochowska, Monika, Dmochowski, Marian
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 22.11.2021
Subjects
autoimmune blistering
bullous pemphigoid
COVID-19
infants
Medicine
RT-PCR
COVID-19
bullous pemphigoid
infants
autoimmune blistering
RT-PCR
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Summary:Bullous pemphigoid (BP) is a cutaneous disease triggered by numerous stimuli, where genetic milieu-influenced autoimmunity to hemidesmosomal proteins, namely, BP180 and/or BP230 initiate an inflammation leading to dermal-epidermal junction (DEJ) enzymatic pathological remodelling. Here, to the best of our knowledge, we present the first case of an infantile BP apparently triggered by COVID-19. BP should be included in differential diagnosis of infantile rashes showing blisters or vesicles or both as well as their prodromal and evolutionary lesions. Possible triggers, such as coronavirus disease 2019 (COVID-19), of BP in infancy should be identified and properly dealt with.
Bibliography:Edited by: Angelo Valerio Marzano, University of Milan, Italy
Reviewed by: Artem Vorobyev, University Medical Center Schleswig-Holstein, Germany; Takashi Hashimoto, Osaka City University, Japan
This article was submitted to Dermatology, a section of the journal Frontiers in Medicine
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2021.760823